RT Book, Section
A1 Sease, Julie
A2 Sutton, S. Scott
SR Print(0)
ID 1179735051
T1 Liver Cirrhosis and Complications
T2 McGraw Hill’s NAPLEX® Review Guide, 4e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781264258062
LK accesspharmacy.mhmedical.com/content.aspx?aid=1179735051
RD 2024/04/18
AB Cirrhosis  (or  end-stage  liver  disease)  is  an  advanced  state  of  liver  fibrosis.  Fibrosis  is  the  replacement  of  injured  tissue  by  scar  tissue  and  is  accompanied  by  a  distortion  of  the  hepatic  vasculature  leading  to  shunting  of  hepatic  blood  supply.  The  shunting  compromises  exchange  between  hepatic  sinusoids  and  hepatocytes  altering  the  functions  of  the  liver.  The  complications  of  cirrhosis  include  impaired  hepatocyte  function,  portal  hypertension,  esophageal  varices,  ascites,  spontaneous  bacterial  peritonitis,  hepatic  encephalopathy,  thrombocytopenia,  coagulopathies,  hepatocellular  carcinoma,  hepatorenal  syndrome,  and  hepatopulmonary  syndrome.  Cirrhosis  may  be  asymptomatic  or  encompass  a  variety  of  symptoms.  Symptoms  of  cirrhosis  include  jaundice,  spider  angiomas,  splenomegaly,  ascites,  palmar  erythema,  gynecomastia,  hypogonadism,  anorexia,  fatigue,  weight  loss,  muscle  wasting,  and  type  2  diabetes.