RT Book, Section
A1 Bimpasis, Lisa (Lubsch)
A2 Sutton, S. Scott
SR Print(0)
ID 1179735415
T1 Cystic Fibrosis
T2 McGraw Hill’s NAPLEX® Review Guide, 4e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781264258062
LK accesspharmacy.mhmedical.com/content.aspx?aid=1179735415
RD 2024/04/20
AB Cystic  fibrosis  (CF)  is  a  life-threatening  genetic  disease  of  the  epithelial  cells  in  the  body,  especially  those  lining  the  intestinal  tract  and  lungs.  Normally,  epithelial  cells  transport  chloride  through  the  cystic  fibrosis  transmembrane  regulator  (CFTR)  with  sodium  and  water  following  the  ion  flux.  CF  is  the  loss  of  the  function  of  the  CFTR  with  defective  movement  of  chloride  and  water  in  the  body.  Thus,  the  composition  of  fluid  secreted  by  the  pancreas,  airways,  and  other  organs  is  thick  and  leads  to  obstruction  with  malfunction.  This  malfunction  eventually  leads  to  widespread  organ  system  disease  (Table  47-1).