RT Book, Section
A1 Bottenberg, Michelle M.
A1 Bryant, Ginelle
A1 Butler, Jared
A2 Sutton, S. Scott
SR Print(0)
ID 1179735467
T1 Gout
T2 McGraw Hill’s NAPLEX® Review Guide, 4e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781264258062
LK accesspharmacy.mhmedical.com/content.aspx?aid=1179735467
RD 2024/04/19
AB Gout  is  characterized  by  acute  and  recurrent  arthritis  mediated  by  the  formation  of  monosodium  uric  (MSU)  acid  crystals  within  the  joints  and  surrounding  tissues.  This  results  in  pain,  erythema,  and  inflammation.  Elevated  serum  uric  acid  (SUA)  concentrations  may  predispose  a  patient  to  symptoms  of  gout.  This  elevation  is  traditionally  a  result  of  a  defect  in  purine  metabolism,  a  decrease  in  uric  acid  excretion,  increased  nucleic  acid  turnover,  or  increased  purine  production.  Regardless  of  the  cause,  excessive  intake  of  high  purine  foods  contributes  to  hyperuricemia  and  gout  exacerbations  (Table  48-1).  SUA  concentrations  are  higher  in  obesity,  chronic  kidney  disease,  and  in  patients  who  consume  alcohol.  However,  gout  flares  can  occur  in  individuals  with  normal  SUA  levels  and  elevated  SUA  concentrations  do  not  always  lead  to  the  development  of  gout.