RT Book, Section A1 Barnes, Kylie N. A1 Guthrie, Kendall D. A2 Sutton, S. Scott SR Print(0) ID 1179735503 T1 Osteoporosis T2 McGraw Hill’s NAPLEX® Review Guide, 4e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781264258062 LK accesspharmacy.mhmedical.com/content.aspx?aid=1179735503 RD 2024/04/20 AB Osteoporosis is characterized by bone loss, reduced bone strength, and deterioration of skeletal microarchitecture resulting in fragile bones. Due to decreased bone strength and quality, fracture risk is increased, particularly of the hip, spine, and wrist. Osteoporosis-related fractures are described as a fracture in adulthood that occurs with trauma less than or equal to a fall from standing height, excluding the fingers, toes, face, and skull. In the United States, women have a higher osteoporotic fracture risk compared to men, likely due to postmenopausal bone loss and lower peak bone mass. Adult peak bone mass is primarily regulated by physical activity, reproductive endocrine status, and calcium intake, with peak bone mass attainment generally occurring in the third decade of life.