RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180555824
T1 Diuretics & Other Drugs That Act on the Kidney
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accesspharmacy.mhmedical.com/content.aspx?aid=1180555824
RD 2024/04/19
AB Drugs  that  act  on  the  kidney  have  important  applications  in  renal,  cardiovascular,  and  endocrine  disorders.  These  disorders  mainly  involve  sodium  and  water  homeostasis.  Each  segment  of  the  nephron—proximal  convoluted  tubule  (PCT),  thick  ascending  limb  (TAL)  of  the  loop  of  Henle,  distal  convoluted  tubule  (DCT),  and  cortical  collecting  tubule  (CCT)—has  a  different  mechanism  for  reabsorbing  sodium  and  other  ions.  The  subgroups  of  the  sodium-excreting  diuretics  are  based  on  these  sites  and  processes  in  the  nephron.  Several  other  drugs  mainly  alter  water  excretion.  The  effects  of  the  diuretic  agents  are  predictable  from  knowledge  of  the  function  of  the  segment  of  the  nephron  in  which  they  act.