RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180555951
T1 Histamine, Serotonin, Drugs Used in Obesity, Ergot Alkaloids, & Other Drugs Used in Migraine
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accesspharmacy.mhmedical.com/content.aspx?aid=1180555951
RD 2024/04/18
AB Autacoids  are  endogenous  molecules  that  do  not  fall  into  traditional  autonomic  groups.  They  do  not  act  on  cholinoceptors  or  adrenoceptors  but  have  powerful  pharmacologic  effects  on  smooth  muscle  and  other  tissues.  Histamine  and  serotonin  (5-hydroxytryptamine;  5-HT)  are  the  most  important  amine  autacoids.  The  drugs  used  in  obesity  do  not  have  significant  smooth  muscle  effects  but  have  some  properties  in  common  with  the  histamine  and  serotonin  groups.  The  ergot  alkaloids  are  a  heterogeneous  group  of  drugs  (not  autacoids)  that  interact  with  serotonin  receptors,  dopamine  receptors,  and  α  receptors.  They  are  included  in  this  chapter  because  of  their  effects  on  serotonin  receptors  and  on  smooth  muscle.  Several  drugs  used  only  for  migraine  headache  target  the  calcitonin  gene-related  peptide  receptor.  Other  peptide  and  eicosanoid  autacoids  are  discussed  in  Chapters  17  and  18.  Nitric  oxide  is  discussed  in  Chapter  19.