RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180557908
T1 Aminoglycosides & Spectinomycin
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accesspharmacy.mhmedical.com/content.aspx?aid=1180557908
RD 2024/04/19
AB In  the  antimicrobial  treatment  of  infections,  multiple  daily  dosage  regimens  traditionally  have  been  designed  to  maintain  serum  concentrations  above  the  minimal  inhibitory  concentration  (MIC)  for  as  long  as  possible.  However,  the  in  vivo  effectiveness  of  some  antibiotics,  including  aminoglycosides,  results  from  concentration-dependent  killing.  As  the  plasma  level  increases  above  the  MIC,  aminoglycosides  kill  an  increasing  proportion  of  bacteria  and  at  an  increasingly  rapid  rate.  Many  other  antibiotics,  including  penicillins  and  cephalosporins,  cause  time-dependent  killing  of  microorganisms:  their  in  vivo  efficacy  is  directly  related  to  time  above  MIC  and  is  independent  of  concentration  once  the  MIC  has  been  reached.