RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180558317
T1 Antiviral Agents
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accesspharmacy.mhmedical.com/content.aspx?aid=1180558317
RD 2024/04/20
AB The  replication  of  viruses  depends  on  synthetic  processes  of  the  host  cell.  Antiviral  drugs  can  exert  their  actions  at  several  stages  of  viral  replication  including  viral  entry,  nucleic  acid  synthesis  and  integration,  late  protein  synthesis,  and  processing,  as  well  as  in  the  final  stages  of  viral  packaging  and  virion  release  (Figure  49–1).  Most  of  the  drugs  active  against  herpes  simplex  viruses  (HSV)  and  many  agents  active  against  human  immunodeficiency  virus  (HIV)  are  antimetabolites,  structurally  similar  to  naturally  occurring  compounds.  The  selective  toxicity  of  antiviral  drugs  usually  depends  on  greater  susceptibility  of  viral  enzymes  to  their  inhibitory  actions  than  host  cell  enzymes.One  of  the  most  important  trends  in  viral  chemotherapy,  especially  in  the  management  of  HIV  infection,  has  been  the  introduction  of  combination  drug  therapy.  This  can  result  in  greater  clinical  effectiveness  in  viral  infections  and  can  also  prevent,  or  delay,  the  emergence  of  resistance.