RT Book, Section
A1 Stringer, Janet L.
SR Print(0)
ID 1187634179
T1 Folate Antagonists
T2 Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264264841
LK accesspharmacy.mhmedical.com/content.aspx?aid=1187634179
RD 2024/04/19
AB To  understand  the  mechanism  of  action  of  this  class  of  drugs,  we  need  to  first  review  the  synthesis  of  folic  acid  (Figure  30–1).  Bacteria  cannot  absorb  folic  acid  but  must  make  it  from  PABA  (para-aminobenzoic  acid),  pteridine,  and  glutamate.  For  humans,  folic  acid  is  a  vitamin.  We  cannot  synthesize  it.  This  makes  this  metabolic  pathway  a  nice,  selective  target  for  antimicrobial  agents.