RT Book, Section
A1 Stringer, Janet L.
SR Print(0)
ID 1187634228
T1 Drugs Used in Tuberculosis and Leprosy
T2 Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264264841
LK accesspharmacy.mhmedical.com/content.aspx?aid=1187634228
RD 2024/04/19
AB The  mycobacteria  that  cause  tuberculosis  and  leprosy  are  very  slow  growing,  so  therapy  must  be  continued  for  relatively  long  periods  of  time.  The  cell  wall  of  these  bacteria  is  more  than  60%  lipid,  mostly  mycolic  acids.  To  prevent  the  emergence  of  resistant  strains,  it  is  vital  to  employ  combination  therapy  with  as  many  as  four  or  five  agents  to  which  the  organism  is  sensitive.  The  current  treatment  regimen  for  tuberculosis  (TB)  (which  is  subject  to  change)  is  2  months  of  isoniazid,  rifampin,  pyrazinamide,  and  ethambutol,  followed  by  4  months  of  isoniazid  and  rifampin.  Increasing  the  duration  of  therapy  or  changing  the  choice  of  drugs  depends  on  culture  and  sensitivity  results  and  factors  that  increase  risk  of  treatment  failure.