RT Book, Section
A1 Ducharme, Murray P.
A1 Wu, Fang
A1 Zhao, Liang
A2 Ducharme, Murray P.
A2 Shargel, Leon
SR Print(0)
ID 1188768847
T1 Pharmacokinetic Calculations for Drug Elimination and Clearance
T2 Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781260142990
LK accesspharmacy.mhmedical.com/content.aspx?aid=1188768847
RD 2024/04/19
AB Discuss  the  clinical  role  of  clearance  as  a  PK  parameter.Calculate  clearance  using  different  methods  including  the  noncompartmental,  compartmental,  and  “physiological”  approaches.Define  clearance  and  its  relationship  to  a  corresponding  half-life  and  a  volume  of  distribution.Differentiate  between  total,  hepatic,  and  renal  clearances.Describe  the  processes  for  renal  drug  excretion  and  explain  which  renal  excretion  process  predominates  in  the  kidney  for  a  specific  drug  given  its  renal  clearance.Describe  the  renal  clearance  model  based  on  renal  blood  flow,  glomerular  filtration,  and  drug  reabsorption.Be  able  to  calculate  if  a  change  in  hepatic  or  renal  clearance  will  have  a  significant  effect  or  not.Describe  hepatic  drug  clearance  in  terms  of  blood  flow  and  extraction  using  the  “physiologic”  well-stirred  model.Predict  the  impact  of  a  drug−drug  interaction  on  protein  binding  or  intrinsic  clearance  on  the  liver  and  total  drug  clearances,  unbound  exposure,  and  oral  bioavailability  for  low  and  highly  extracted  drugs  using  the  “physiologic”  well-stirred  model.