RT Book, Section A1 Yue, Corinne Seng A1 Al-Numani, Dina A2 Ducharme, Murray P. A2 Shargel, Leon SR Print(0) ID 1188769114 T1 Pharmacokinetics of Drug Absorption T2 Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781260142990 LK accesspharmacy.mhmedical.com/content.aspx?aid=1188769114 RD 2024/03/28 AB Define oral drug absorption and its relevance.Describe different absorption rate processes (eg, first- and zero-order).Calculate the pharmacokinetic parameters of an orally administered drug that is described by a one-compartment model.Calculate the absorption rate constant for an orally administered drug that is described by a two-compartment pharmacokinetic model.Contrast current methods for characterizing absorption against historical methods.Describe flip-flop kinetics for oral extended-release drug products.Discuss the clinical implication of absorption half-life.Discuss how ka and kel influence Cmax, tmax, and AUC.Discuss how changes in these parameters affect drug safety in a clinical situation.