RT Book, Section
A1 Yue, Corinne Seng
A1 Colucci, Philippe
A1 Ducharme, Murray P.
A2 Ducharme, Murray P.
A2 Shargel, Leon
SR Print(0)
ID 1188769989
T1 Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental PK/PD Analyses
T2 Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, 8e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781260142990
LK accesspharmacy.mhmedical.com/content.aspx?aid=1188769989
RD 2024/04/24
AB Describe  the  differences  between  empirical  and  mechanistic  models.Understand  the  differences  between  different  types  of  compartmental  analyses.Describe  the  physiologic  pharmacokinetic  (PBPK)  model  with  equations  and  underlying  assumptions.List  the  advantages  and  disadvantages  related  to  the  use  of  PBPK,  population  PK,  and  the  noncompartmental  PK  approaches  for  data  analyses  and  predictions.Describe  interspecies  scaling  and  its  application  in  pharmacokinetics  and  toxicokinetics.Describe  statistical  moment  theory  and  explain  how  it  provides  a  unique  way  to  study  time-related  changes  in  macroscopic  events.Define  mean  residence  time  (MRT)  and  how  it  can  be  calculated.Define  mean  transit  time  (MTT)  and  how  it  can  be  used  to  calculate  the  mean  dissolution  time  (MDT),  or  in  vivo  mean  dissolution  time,  for  a  solid  drug  product  given  orally.Estimate  other  PK  parameters  such  as  mean  absorption  time  and  total  volume  of  distribution  using  MRT