RT Book, Section
A1 Klaunig, James E.
A1 Kamendulis, Lisa M.
A2 Klaassen, Curtis D.
A2 Watkins, John B.
SR Print(0)
ID 6480913
T1 Chapter 8. Chemical Carcinogenesis
T2 Casarett & Doull's Essentials of Toxicology, 2e
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-162240-0
LK accesspharmacy.mhmedical.com/content.aspx?aid=6480913
RD 2024/04/23
AB The  term  cancer  describes  a  subset  of  neoplastic  lesions.A  neoplasm  is  defined  as  a  heritably  altered,  relatively  autonomous  growth  of  tissue  with  abnormal  regulation  of  gene  expression.Metastases  are  secondary  growths  of  cells  from  the  primary  neoplasm.A  carcinogen  is  an  agent  whose  administration  to  previously  untreated  animals  leads  to  a  statistically  significant  increased  incidence  of  neoplasms  of  one  or  more  histogenetic  types  as  compared  with  the  incidence  in  appropriate  untreated  animals.Initiation  requires  one  or  more  rounds  of  cell  division  for  the  “fixation”  of  the  DNA  damage.Promotion  results  from  the  selective  functional  enhancement  of  the  initiated  cell  and  its  progeny  by  the  continuous  exposure  to  the  promoting  agent.Progression  is  the  transition  from  early  progeny  of  initiated  cells  to  the  biologically  malignant  cell  population  of  the  neoplasm.