RT Book, Section
A1 Rice, Robert H.
A1 Mauro, Theodora M.
A2 Klaassen, Curtis D.
A2 Watkins, John B.
SR Print(0)
ID 6484631
T1 Chapter 19. Toxic Responses of the Skin
T2 Casarett & Doull's Essentials of Toxicology, 2e
YR 2010
FD 2010
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-162240-0
LK accesspharmacy.mhmedical.com/content.aspx?aid=6484631
RD 2023/11/30
AB The  skin  participates  directly  in  thermal,  electrolyte,  hormonal,  metabolic,  and  immune  regulation.Percutaneous  absorption  depends  on  the  xenobiotic's  hydrophobicity,  which  affects  its  ability  to  partition  into  epidermal  lipid,  and  rate  of  diffusion  through  this  barrier.The  cells  of  the  epidermis  and  pilosebaceous  units  express  biotransformation  enzymes.Irritant  dermatitis  is  a  nonimmune-related  response  caused  by  the  direct  action  of  an  agent  on  the  skin.Allergic  contact  dermatitis  represents  a  delayed  (type  IV)  hypersensitivity  reaction,  whereby  minute  quantities  of  material  elicit  overt  reactions.