RT Book, Section
A1 Bauer, Larry A.
A2 Bauer, Larry A.
SR Print(0)
ID 3518598
T1 Chapter 2. Clinical Pharmacokinetic Equations and Calculations
T2 Applied Clinical Pharmacokinetics, 2e
YR 2008
FD 2008
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-147628-7
LK accesspharmacy.mhmedical.com/content.aspx?aid=3518598
RD 2024/04/24
AB Clinical  pharmacokinetic  dosage  calculations  are  conducted  using  the  easiest  possible  equations  and  methods.  This  is  because  there  are  usually  only  a  few  (sometimes  as  little  as  1–2)  drug  serum  concentrations  on  which  to  base  the  calculations.  Drug  serum  concentrations  are  expensive  (typically  $25–75  each),  and  obtaining  them  can  cause  minor  discomfort  and  trauma  to  the  patient.  This  situation  is  much  different  than  that  found  in  pharmacokinetic  research  studies  where  there  may  be  10–15  drug  serum  concentrations  used  to  calculate  pharmacokinetic  parameters,  and  more  complex  equations  can  be  used  to  describe  the  pharmacokinetics  of  the  drug.  Since  the  goal  of  therapeutic  drug  monitoring  in  patients  is  to  individualize  the  drug  dose  and  serum  concentrations  in  order  to  produce  the  desired  pharmacological  effect  and  avoid  adverse  effects,  it  may  not  be  possible,  or  even  necessary,  to  compute  pharmacokinetic  parameters  for  every  patient  or  clinical  situation.