RT Book, Section
A1 Bauer, Larry A.
A2 Bauer, Larry A.
SR Print(0)
ID 3517091
T1 Chapter 10. Phenytoin
T2 Applied Clinical Pharmacokinetics, 2e
YR 2008
FD 2008
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-147628-7
LK accesspharmacy.mhmedical.com/content.aspx?aid=3517091
RD 2024/04/19
AB Phenytoin  is  a  hydantoin  compound  related  to  the  barbiturates  that  are  used  for  the  treatment  of  seizures.  It  is  an  effective  anticonvulsant  for  the  chronic  treatment  of  tonic-clonic  (grand  mal)  or  partial  seizures  and  the  acute  treatment  of  generalized  status  epilepticus  (Table  10-1).1,2  After  generalized  status  epilepticus  has  been  controlled  with  intravenous  benzodiazepine  therapy  and  supportive  measures  have  been  instituted,  phenytoin  therapy  is  usually  immediately  instituted  with  the  administration  of  intravenous  phenytoin  or  fosphenytoin.  Orally  administered  phenytoin  is  used  chronically  to  provide  prophylaxis  against  tonic-clonic  or  partial  seizures.  Phenytoin  is  a  type  1B  antiarrhythmic  and  is  also  used  in  the  treatment  of  trigeminal  neuralgia.