RT Book, Section
A1 Sutton, S. Scott
A2 Sutton, S. Scott
SR Print(0)
ID 7251469
T1 Chapter 19. Antimicrobial Regimen Selection
T2 McGraw-Hill's NAPLEX® Review Guide
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-175562-7
LK accesspharmacy.mhmedical.com/content.aspx?aid=7251469
RD 2024/04/18
AB Antimicrobials  vary  in  their  ability  to  inhibit  or  kill  different  species  of  bacteria.  Antimicrobials  that  kill  many  different  species  of  bacteria  are  called  broad-spectrum,  whereas  antimicrobials  that  kill  a  few  different  species  of  bacteria  are  called  narrow-spectrum  antimicrobials.  Empirically  treating  infectious  diseases  and  monitoring  therapy  requires  knowledge  of  anti-infective  properties,  host  factors,  patient's  normal  flora,  differentiating  infection  versus  colonization,  and  understanding  clinical  presentation  and  diagnostic  tests  (microbiologic  and  nonmicrobiologic  laboratory  studies).1,2  Broad  spectrum  anti-infective  coverage  increases  the  likelihood  of  empirically  targeting  a  causative  pathogen;  unfortunately,  the  development  of  secondary  infections  caused  by  selection  of  antimicrobial-resistant  pathogens  is  a  common  problem.  In  addition,  adverse  events  may  complicate  up  to  10%  of  antimicrobial  therapy  (adverse  event  rate  is  higher  for  select  agents).3,4