RT Book, Section A1 Shargel, Leon A1 Wu-Pong, Susanna A1 Yu, Andrew B.C. SR Print(0) ID 56601742 T1 Chapter 4. Multicompartment Models: Intravenous Bolus Administration T2 Applied Biopharmaceutics & Pharmacokinetics, 6e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160393-5 LK accesspharmacy.mhmedical.com/content.aspx?aid=56601742 RD 2024/03/28 AB Pharmacokinetic models are used to simplify all the complex processes that occur during drug administration that include drug distribution and elimination in the body. The model simplification is necessary because of the inability to measure quantitatively all the rate processes in the body, including the lack of access to biological samples from the interior of the body. As described in Chapter 3, pharmacokinetic models are used to simulate drug disposition so dosing regimens for individuals or groups of patients can be calculated.