RT Book, Section
A1 Shargel, Leon
A1 Wu-Pong, Susanna
A1 Yu, Andrew B.C.
SR Print(0)
ID 56602910
T1 Chapter 9. Nonlinear Pharmacokinetics
T2 Applied Biopharmaceutics & Pharmacokinetics, 6e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160393-5
LK accesspharmacy.mhmedical.com/content.aspx?aid=56602910
RD 2024/04/20
AB Previous  chapters  discussed  linear  pharmacokinetic  models  using  simple  first-order  kinetics  to  describe  the  course  of  drug  disposition  and  action.  These  linear  models  assumed  that  the  pharmacokinetic  parameters  for  a  drug  would  not  change  when  different  doses  or  multiple  doses  of  a  drug  were  given.  With  some  drugs,  increased  doses  or  chronic  medication  can  cause  deviations  from  the  linear  pharmacokinetic  profile  previously  observed  with  single  low  doses  of  the  same  drug.  This  nonlinear  pharmacokinetic  behavior  is  also  termed  dose-dependentpharmacokinetics.