RT Book, Section A1 Shargel, Leon A1 Wu-Pong, Susanna A1 Yu, Andrew B.C. SR Print(0) ID 56604389 T1 Chapter 13. Physiologic Factors Related to Drug Absorption T2 Applied Biopharmaceutics & Pharmacokinetics, 6e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-160393-5 LK accesspharmacy.mhmedical.com/content.aspx?aid=56604389 RD 2024/11/13 AB Major considerations in the design of a drug product include the therapeutic objective, the application site, and systemic drug absorption from the application site. If the drug is intended for systemic activity, the drug should ideally be completely and consistently absorbed from the application site. In contrast, if the drug is intended for local activity, then systemic absorption from the application should be minimal to prevent systemic drug exposure and possible systemic side effects. For extended-release drug products, the drug product should remain at or near the application site and then slowly release the drug for the desired period of time. The systemic absorption of a drug is dependent on (1) the physicochemical properties of the drug, (2) the nature of the drug product, and (3) the anatomy and physiology of the drug absorption site.