RT Book, Section
A1 Trevor, Anthony J.
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke M.
A1 Masters, Susan B.
SR Print(0)
ID 56982301
T1 Chapter 29. Antipsychotic Agents & Lithium
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 10e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-178923-3
LK accesspharmacy.mhmedical.com/content.aspx?aid=56982301
RD 2024/04/20
AB The  antipsychotic  drugs  (neuroleptics)  are  used  in  schizophrenia  and  are  also  effective  in  the  treatment  of  other  psychoses  and  agitated  states.  Older  drugs  have  high  affinity  for  dopamine  D2  receptors,  whereas  newer  antipsychotic  drugs  have  greater  affinity  for  serotonin5-HT2  receptors.  Although  schizophrenia  is  not  cured  by  drug  therapy,  the  symptoms,  including  thought  disorder,  emotional  withdrawal,  and  hallucinations  or  delusions,  may  be  ameliorated  by  antipsychotic  drugs.  Unfortunately,  protracted  therapy  (years)  is  often  needed  and  can  result  in  severe  toxicity  in  some  patients.  In  bipolar  affective  disorder,  although  lithium  has  been  the  mainstay  of  treatment  for  many  years,  the  use  of  newer  antipsychotic  agents  and  of  several  antiseizure  drugs  is  increasing.