RT Book, Section A1 Trevor, Anthony J. A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke M. A1 Masters, Susan B. SR Print(0) ID 56983555 T1 Chapter 42. Drugs that Affect Bone Mineral Homeostasis T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 10e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-178923-3 LK accesspharmacy.mhmedical.com/content.aspx?aid=56983555 RD 2024/03/29 AB Calcium and phosphorus, the 2 major elements of bone, are crucial not only for the mechanical strength of the skeleton but also for the normal function of many other cells in the body. Accordingly, a complex regulatory mechanism has evolved to tightly regulate calcium and phosphate homeostasis. Parathyroid hormone (PTH) and vitamin D are primary regulators (Figure 42–1), whereas calcitonin, glucocorticoids, and estrogens play secondary roles. These hormones or drugs that mimic or suppress their actions are used in the treatment of bone mineral disorders (eg, osteoporosis, rickets, osteomalacia, Paget's disease), as are several nonhormonal agents.