RT Book, Section
A1 Trevor, Anthony J.
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke M.
A1 Masters, Susan B.
SR Print(0)
ID 56985711
T1 Part VIII Chemotherapeutic Drugs
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 10e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-178923-3
LK accesspharmacy.mhmedical.com/content.aspx?aid=56985711
RD 2024/04/25
AB The  emergence  of  microbial  resistance  poses  a  constant  challenge  to  the  use  of  antimicrobial  drugs.  Mechanisms  underlying  microbial  resistance  to  cell  wall  synthesis  inhibitors  include  the  production  of  antibiotic-inactivating  enzymes,  changes  in  the  structure  of  target  receptors,  increased  efflux  via  drug  transporters,  and  decreases  in  the  permeability  of  microbes'  cellular  membranes  to  antibiotics.  Strategies  designed  to  combat  microbial  resistance  include  the  use  of  adjunctive  agents  that  can  protect  against  antibiotic  inactivation,  the  use  of  antibiotic  combinations,  the  introduction  of  new  (and  often  expensive)  chemical  derivatives  of  established  antibiotics,  and  efforts  to  avoid  the  indiscriminate  use  or  misuse  of  antibiotics.