RT Book, Section A1 Trevor, Anthony J. A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke M. A1 Masters, Susan B. SR Print(0) ID 56984056 T1 Chapter 48. Antifungal Agents T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 10e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-178923-3 LK accesspharmacy.mhmedical.com/content.aspx?aid=56984056 RD 2024/03/28 AB Fungal infections are difficult to treat, particularly in the immunocompromised or neutropenic patient. Most fungi are resistant to conventional antimicrobial agents, and relatively few drugs are available for the treatment of systemic fungal diseases. Amphotericin B and the azoles (fluconazole, itraconazole, ketoconazole, and voriconazole) are the primary drugs used in systemic infections. They are selectively toxic to fungi because they interact with or inhibit the synthesis of ergosterol, a sterol unique to fungal cell membranes.