RT Book, Section A1 Trevor, Anthony J. A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke M. A1 Masters, Susan B. SR Print(0) ID 56984153 T1 Chapter 49. Antiviral Chemotherapy & Prophylaxis T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 10e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-178923-3 LK accesspharmacy.mhmedical.com/content.aspx?aid=56984153 RD 2024/03/28 AB As obligate intracellular parasites, the replication of viruses depends on synthetic processes of the host cell. Antiviral drugs can exert their actions at several stages of viral replication including viral entry, nucleic acid synthesis, late protein synthesis and processing, and in the final stages of viral packaging and virion release (Figure 49–1). Most of the drugs active against herpes viruses (HSV) and many agents active against human immunodeficiency virus (HIV) are antimetabolites, structurally similar to naturally occurring compounds. The selective toxicity of antiviral drugs usually depends on greater susceptibility of viral enzymes to their inhibitory actions than host cell enzymes.