RT Book, Section A1 Brady, Rebecca L. A1 Hall, Reed C. A2 Attridge, Rebecca L. A2 Miller, Monica L. A2 Moote, Rebecca A2 Ryan, Laurajo SR Print(0) ID 57295748 T1 Chapter 46. Solid Organ Transplantation T2 Internal Medicine: A Guide to Clinical Therapeutics YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-174580-2 LK accesspharmacy.mhmedical.com/content.aspx?aid=57295748 RD 2024/03/29 AB Curative treatment for end-stage organ diseasePrevalence of transplants ↑ with improved surgical techniques, immunosuppression regimens, & disease state management leading up to transplantLiver: chronic noncholestatic liver disorders (most common reasons for transplant)→ chronic HCV, EtOH, chronic HBV; cholestatic liver disorders → primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC); other reasons for transplant → metabolic disorders causing cirrhosis, &/or severe extrahepatic morbidity, primary hepatic malignancies, fulminant hepatic failure, retransplant, NASH (nonalcoholic steatohepatitis)Kidney: DM, HTN, GN, PCKD, hypertensive nephrosclerosis, congenital, familial & metabolic diseases, tubular & interstitial diseases, neoplasms, retransplantHeart: CAD, cardiomyopathy, congenital heart disease, valvular heart diseaseLung: emphysema/COPD, cystic fibrosis, idiopathic pulmonary fibrosis, α1-antitrypsin deficiency, idiopathic pulmonary arterial hypertension, congenital diseasePancreas: type 1 DM complicated by severe hypoglycemia unawareness or hyperlabilityIntestine: short gut syndrome, functional bowel problem