RT Book, Section
A1 Parkinson, Andrew
A1 Ogilvie, Brian W.
A1 Buckley, David B.
A1 Kazmi, Faraz
A1 Czerwinski, Maciej
A1 Parkinson, Oliver
SR Print(0)
ID 1100085332
T1 Biotransformation of Xenobiotics
T2 Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e
YR 2012
FD 2012
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-176925-9
LK accesspharmacy.mhmedical.com/content.aspx?aid=1100085332
RD 2024/04/19
AB IntroductionPrinciples  of  Xenobiotic  BiotransformationHydrolysis,  Reduction,  and  OxidationHydrolysisCarboxylesterasesCholinesterases  (AChE  and  BChE)Paraoxonases  (Lactonases)Prodrugs  and  Alkaline  PhosphatasePeptidasesβ-GlucuronidaseEpoxide  HydrolasesReductionAzo-  and  Nitro-ReductionCarbonyl  Reduction—AKRs  and  SDRsDisulfide  ReductionSulfoxide  and  N-Oxide  ReductionQuinone  Reduction—NQO1  and  NQO2Dihydropyrimidine  DehydrogenaseDehalogenationDehydroxylation—mARC,  Cytochrome  b5,  b5Reductase,  and  Aldehyde  OxidaseAldehyde  Oxidase—Reductive  ReactionsOxidationAlcohol,  Aldehyde,  Ketone  Oxidation–Reduction  SystemsAlcohol  DehydrogenaseAldehyde  DehydrogenaseDimeric  Dihydrodiol  DehydrogenaseMolybdenum  Hydroxylases  (Molybdoenzymes)Xanthine  OxidoreductaseAldehyde  OxidaseAmine  OxidasesAromatizationPeroxidase-Dependent  CooxidationFlavin  MonooxygenasesCytochrome  P450Activation  of  Xenobiotics  byCytochrome  P450Inhibition  of  Cytochrome  P450Induction  of  Cytochrome  P450—XenosensorsConjugationGlucuronidation  and  Formationof  Acyl-CoA  ThioestersSulfonationMethylationAcetylationAmino  Acid  ConjugationGlutathione  ConjugationThiosulfate  Sulfurtransferase  (Rhodanese)Unusual  Conjugation  ReactionsPhosphorylation