RT Book, Section
A1 Smith, Silas W.
A1 Howland, Mary Ann
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108421329
T1 Antidotes in Depth
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108421329
RD 2024/04/20
AB To  alter  xenobiotic  pharmacokinetics,  the  approach  to  a  poisoned  patient  may  include  administration  of  gastrointestinal  (GI)  evacuants.  Selected  patients  may  benefit  from  minimizing  systemic  exposure  by  decreasing  GI  transit  time  and  increasing  rectal  expulsion.  The  most  effective  process  of  evacuating  the  GI  tract  in  poisoned  patients  is  referred  to  as  whole-bowel  irrigation  (WBI).  WBI  is  typically  accomplished  using  polyethylene  glycol  with  a  balanced  electrolyte  lavage  solution  (PEG-ELS).  A  detailed  discussion  of  the  merits  of  WBI  in  the  context  of  various  decontamination  strategies  is  provided  in  Chap.  8.