RT Book, Section
A1 Smith, Silas W.
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108421846
T1 Antidotes in Depth
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108421846
RD 2024/04/20
AB Glucarpidase  (carboxypeptidase  G2,  CPDG2)  is  indicated  for  the  manage­ment  of  methotrexate  (MTX)  toxicity.  When  given  intravenously  or  intrathecally,  it  rapidly  enzymatically  inactivates  MTX,  folates  and  folate  analogues.  It  does  not  substitute  for  and  must  be  used  in  conjunction  with  leucovorin  (Antidotes  in  Depth:  A10).  Leucovorin  should  not  be  administered  within  two  hours  before  or  after  a  dose  of  glucarpidase.