RT Book, Section
A1 Howland, Mary Ann
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108422002
T1 Antidotes in Depth
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108422002
RD 2024/04/25
AB Pyridoxine  (vitamin  B6),  a  water-soluble  vitamin,  is  an  antidote  for  overdoses  of  isonicotinic  acid  hydrazide  (Isoniazid,  INH),  Gyromitra  esculenta  mushrooms,  hydrazine,  methylated  hydrazines,  and  ethylene  glycol.  With  the  exception  of  ethylene  glycol,  all  of  these  xenobiotics  produce  seizures  by  the  competitive  inhibition  of  pyridoxal-5′-phosphate  (PLP).  Pyridoxine  overcomes  this  inhibition  and  may  also  enhance  the  less  toxic  pathway  of  ethylene  glycol  metabolism  to  form  benzoic  and  hippuric  acid,  instead  of  oxalic  acid.6  Hydrazine  and  methylated  hydrazines  (1,1-dimethylhydrazine,  UDMH;  monomethylhydrazine,  MMH)  are  used  as  rocket  fuels,  and  MMH  is  also  found  in  Gyromitra  esculenta  mushrooms.3