RT Book, Section
A1 Howland, Mary Ann
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108423382
T1 Antidotes in Depth
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108423382
RD 2024/04/19
AB Methylene  blue  is  an  extremely  effective  antidote  for  acquired  methemoglobinemia.  Methylene  blue  has  other  actions,  including  the  inhibition  of  nitric  oxide  synthase  and  guanylyl  cyclase,  and  the  inhibition  of  the  generation  of  oxygen  free  radicals.  These  actions  may  explain  the  beneficial  effects  of  methylene  blue  in  the  treatment  of  refractory  hypotension,  hepatopulmonary  syndrome,  treatment  of  priapism,  modulation  of  streptozocin-induced  insulin  deficiency,  prevention  and  treatment  of  ifosfamide-induced  encephalopathy,  in  the  treatment  of  sepsis,  and  the  reduction  of  the  development  of  postsurgical  peritoneal  adhesions.15,16,21,25,34,44,52,59