RT Book, Section
A1 Kleinschmidt, Kurt C.
A1 Delaney, Kathleen A.
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108424950
T1 Biochemical and Metabolic Principles
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108424950
RD 2024/04/19
AB Xenobiotics  are  compounds  that  are  foreign  to  a  living  system.  Toxic  xenobiotics  interfere  with  critical  metabolic  processes,  causing  structural  damage  to  cells  or  altering  their  cellular  genetic  material.  The  specific  biochemical  sites  of  actions  that  disrupt  metabolic  processes  are  well  characterized  for  many  xenobiotics  although  mechanisms  of  cellular  injury  are  not.  This  chapter  reviews  the  biochemical  principles  that  are  relevant  to  an  understanding  of  the  damaging  effects  of  toxic  xenobiotics  and  the  biotransformation  enzymes  and  their  clinical  implications.