RT Book, Section A1 Zuckerman, Matthew D. A1 Church, Richard J. A2 Hoffman, Robert S. A2 Howland, Mary Ann A2 Lewin, Neal A. A2 Nelson, Lewis S. A2 Goldfrank, Lewis R. SR Print(0) ID 1108425966 T1 Gastrointestinal Principles T2 Goldfrank's Toxicologic Emergencies, 10e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071801843 LK accesspharmacy.mhmedical.com/content.aspx?aid=1108425966 RD 2024/03/28 AB Humans are in constant contact with a variety of xenobiotics. In addition to its critical role in absorbing nutrients, the gastrointestinal (GI) tract forms the initial functional barrier between ingested material and the body. An understanding of the GI tract’s structure, physiology, and innervation is critical to the toxicologic concepts of absorption, motility, and toxic insult. This chapter discusses the normal role of the GI tract and its relationship to toxicology. Anatomic, pathologic, and microbiologic principles are discussed, including the role of the GI tract in the metabolism of xenobiotics. Examples of GI pathologies and their clinical manifestations are discussed, with examples when appropriate.