RT Book, Section
A1 Delaney, Kathleen A.
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108426342
T1 Hepatic Principles
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108426342
RD 2024/04/19
AB The  liver  plays  an  essential  role  in  metabolic  homeostasis.  Hepatic  functions  include  the  synthesis,  storage,  and  breakdown  of  glycogen.  In  addition,  the  liver  is  important  in  the  metabolism  of  lipids;  the  synthesis  of  albumin,  clotting  factors,  and  other  important  proteins;  the  synthesis  of  the  bile  acids  necessary  for  absorption  of  lipids  and  lipid  soluble  vitamins;  and  the  metabolism  of  cholesterol.64,159  Hepatocytes  facilitate  the  excretion  of  metals,  most  importantly  iron,  copper,  zinc,  manganese,  mercury,  and  aluminum,  as  well  as  the  detoxification  of  products  of  metabolism,  such  as  bilirubin  and  ammonia.32,74  Generalized  disruption  of  these  important  functions  results  in  manifestations  of  liver  failure:  hyperbilirubinemia,  coagulopathy,  hypoalbuminemia,  hyperammonemia,  and  hypoglycemia.86,89,137  Disturbances  of  more  specific  functions  result  in  accumulation  of  lipids,  metals,  and  ­bilirubin,  and  the  development  of  lipid-soluble  vitamin  deficiencies.64,159