RT Book, Section
A1 Holubek, William J.
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108427970
T1 Nonsteroidal Antiinflammatory Drugs
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108427970
RD 2024/04/19
AB In  the  late  1800s,  acetylsalicylic  acid,  aspirin,  was  shown  to  have  antiinflammatory  properties  similar  to  those  of  corticosteroids  when  used  in  high  doses  in  patients  with  rheumatoid  arthritis.  In  a  quest  to  develop  a  compound  with  antiinflammatory  properties  equivalent  to  corticosteroids  but  chemically  nonsteroidal,  Dr.  Stewart  Adams  discovered  and  developed  2-(4-isobutylphenyl)  propionic  acid,  now  known  as  ibuprofen,  and  in  the  process  created  a  new  class  of  drugs  designated  as  nonsteroidal  antiinflammatory  drugs  (NSAIDs).35  Ibuprofen  was  initially  marketed  in  the  United  Kingdom  in  1969  and  was  introduced  to  the  US  market  in  1974.  Ibuprofen  became  available  without  a  prescription  in  the  United  States  in  1984.