RT Book, Section
A1 Doyon, Suzanne
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108439395
T1 Antiepileptics
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accesspharmacy.mhmedical.com/content.aspx?aid=1108439395
RD 2024/04/16
AB Historically,  seizures  were  treated  by  a  variety  of  methods,  including  ketogenic  diets,  fluid  restriction,  and  surgical  excision  of  scars  or  irritable  ­cortical  foci.  The  first  truly  effective  antiepileptic  therapy  was  introduced  in  1857,  when  the  administration  of  bromides  was  noted  to  sedate  patients  and  significantly  reduce  their  seizures.  Phenobarbital,  a  sedative–hypnotic,  was  first  used  to  treat  seizures  in  1912.  Most  of  the  subsequently  introduced  antiepileptics  such  as  primidone  had  chemical  structures  similar  to  that  of  phenobarbital,  and  sedation  was  erroneously  believed  to  be  an  essential  component  of  antiepileptic  therapy.