RT Book, Section A1 Bauer, Larry A. SR Print(0) ID 1106304021 T1 Lamotrigine T2 Applied Clinical Pharmacokinetics, 3e YR 2015 FD 2015 PB McGraw-Hill Medical PP New York, NY SN 9780071794589 LK accesspharmacy.mhmedical.com/content.aspx?aid=1106304021 RD 2024/03/29 AB Lamotrigine is a phenyltriazine-based compound effective in the treatment of partial and generalized seizures (Table 15-1).1,2,3, and 4 Although lamotrigine is listed as a recommended therapy for absence seizures by expert panels, recent literature suggests that ethosuximide or valproic acid may be more effective initial therapy for this epilepsy type.5,6 It is also useful for the treatment of bipolar disorders, neurogenic pain, and Lennox-Gastaut syndrome.7,8, and 9 While lamotrigine was originally developed as a antifolate agent, its therapeutic effects are not related to this property. The proposed mechanism of action in humans is the inhibition of voltage-sensitive sodium channels, which stabilizes neuronal membranes and modulates the presynaptic transmitter release of glutamate and aspartate.9,10,11, and 12