RT Book, Section A1 Bauer, Larry A. SR Print(0) ID 1106304305 T1 Cyclosporine T2 Applied Clinical Pharmacokinetics, 3e YR 2015 FD 2015 PB McGraw-Hill Medical PP New York, NY SN 9780071794589 LK accesspharmacy.mhmedical.com/content.aspx?aid=1106304305 RD 2024/03/29 AB Cyclosporine is a cyclic polypeptide calcineurin inhibitor with immunosuppressant properties that is used for the prevention of graft-versus-host disease in hematopoietic stem cell transplantation patients, for the prevention of graft rejection in solid organ transplant patients, and for the treatment of psoriasis, rheumatoid arthritis, and a variety of other autoimmune diseases.1,2, and 3 The immunomodulating properties of cyclosporine are due to its ability to block the production of interleukin-2 and other cytokines secreted by T lymphocytes.1,2, and 3 Cyclosporine binds to cyclophilin, an intracellular cytoplasmic protein found in T cells. The cyclosporine-cyclophilin complex interacts with calcineurin, inhibits the catalytic activity of calcineurin, and prevents the production of intermediaries involved with the expression of genes regulating the production of cytokines.