RT Book, Section
A1 Del Valle, John
A2 Kasper, Dennis
A2 Fauci, Anthony
A2 Hauser, Stephen
A2 Longo, Dan
A2 Jameson, J. Larry
A2 Loscalzo, Joseph
SR Print(0)
ID 1129876322
T1 Peptic Ulcer Disease and Related Disorders
T2 Harrison's Principles of Internal Medicine, 19e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071802154
LK accesspharmacy.mhmedical.com/content.aspx?aid=1129876322
RD 2022/06/25
AB Burning  epigastric  pain  exacerbated  by  fasting  and  improved  with  meals  is  a  symptom  complex  associated  with  peptic  ulcer  disease  (PUD).  An  ulcer  is  defined  as  disruption  of  the  mucosal  integrity  of  the  stomach  and/or  duodenum  leading  to  a  local  defect  or  excavation  due  to  active  inflammation.  Ulcers  occur  within  the  stomach  and/or  duodenum  and  are  often  chronic  in  nature.  Acid  peptic  disorders  are  very  common  in  the  United  States,  with  4  million  individuals  (new  cases  and  recurrences)  affected  per  year.  Lifetime  prevalence  of  PUD  in  the  United  States  is  ~12%  in  men  and  10%  in  women.  PUD  significantly  affects  quality  of  life  by  impairing  overall  patient  well-being  and  contributing  substantially  to  work  absenteeism.  Moreover,  an  estimated  15,000  deaths  per  year  occur  as  a  consequence  of  complicated  PUD.  The  financial  impact  of  these  common  disorders  has  been  substantial,  with  an  estimated  burden  on  direct  and  indirect  health  care  costs  of  ~$6  billion  per  year  in  the  United  States,  with  $3  billion  spent  on  hospitalizations,  $2  billion  on  physician  office  visits,  and  $1  billion  in  decreased  productivity  and  days  lost  from  work.