RT Book, Section A1 Powers, Alvin C. A2 Kasper, Dennis A2 Fauci, Anthony A2 Hauser, Stephen A2 Longo, Dan A2 Jameson, J. Larry A2 Loscalzo, Joseph SR Print(0) ID 1120816327 T1 Diabetes Mellitus: Complications T2 Harrison's Principles of Internal Medicine, 19e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071802154 LK accesspharmacy.mhmedical.com/content.aspx?aid=1120816327 RD 2022/07/04 AB Diabetes-related complications affect many organ systems and are responsible for the majority of morbidity and mortality associated with the disease. Strikingly, in the United States, diabetes is the leading cause of new blindness in adults, renal failure, and nontraumatic lower extremity amputation. Diabetes-related complications usually do not appear until the second decade of hyperglycemia. Because type 2 ­diabetes mellitus (DM) often has a long asymptomatic period of hyperglycemia before diagnosis, many individuals with type 2 DM have complications at the time of diagnosis. Fortunately, many of the diabetes-related complications can be prevented or delayed with early detection, aggressive glycemic control, and efforts to minimize the risks of complications.