RT Book, Section
A1 SALTIEL, MANNY
A1 TART, SERINA
A1 KILLIUS, KELLY A.
A1 TRUESDALE, TRACEY H.
A1 PERRODIN, DANIELLE
A1 VERKLEEREN, NICOLE D.
A1 MACEIRA, ERICA
A1 VAUGHAN, CHRISTY
A1 PLEWA, ANGELA M.
A2 Cohen, Henry
SR Print(0)
ID 1112256549
T1 Aminoglycoside Pharmacokinetics
T2 Casebook in Clinical Pharmacokinetics and Drug Dosing
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071628358
LK accesspharmacy.mhmedical.com/content.aspx?aid=1112256549
RD 2024/04/19
AB The  aminoglycoside  class  of  antibiotics  represents  the  class  of  drugs  whose  pharmacokinetics  has  been  studied  more  extensively  than  any  other.  Remarkably  resilient,  these  antibiotics  continue  to  provide  valuable  weapons  in  the  fight  against  infectious  disease.  Yet  their  well-known  toxicities  prevent  their  more  frequent  use.  Clinical  pharmacists  are  expected  to  serve  as  experts  on  the  pharmacokinetic  dosing  of  these  drugs,  and  yet  complex  issues  still  lead  to  misunderstandings  in  their  optimal  use.  In  this  chapter,  several  aspects  of  dosing  will  be  presented:  Extended  interval  dosing  versus  conventional  dosingTraditional  dosing  and  peak  optimizationAminoglycoside  ADRs  related  to  trough  concentrationsAminoglycoside  dosing  in  acute  renal  failureRounding  serum  creatinine  in  the  elderlyAminoglycoside  dosing  in  the  obese  patientAminoglycosides  used  in  the  treatment  of  gram-positive  endocarditisAminoglycosides  pharmacokinetics  in  pediatrics  patients  with  cystic  fibrosis