RT Book, Section A1 GONZALEZ, EDGAR R. A1 GONZALEZ, REBECCA B. A2 Cohen, Henry SR Print(0) ID 1112259255 T1 Quinidine T2 Casebook in Clinical Pharmacokinetics and Drug Dosing YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071628358 LK accesspharmacy.mhmedical.com/content.aspx?aid=1112259255 RD 2024/03/28 AB The medicinal effects of the bark of the cinchona tree have been known for over 350 years. The tree is indigenous to South America and is known as Peruvian, Jesuit's, or Cardinal Bark. During the 1600s and 1700s, Jesuit priests imported cinchona bark from South America to Europe where it was used as a powder, extract, or infusion to treat fevers as well as “rebellious palpitation.”1,2 In the early 1800s, Pelletier and Caventou worked to isolate the more than 20 structurally related alkaloids found in the bark of the cinchona tree, quinine and quinidine being the most important ones.1, 2, and 3 Pelletier and Caventou successfully isolated quinine in 1820 (see Figure 18-1).2,3