RT Book, Section
A1 Shen, Danny D.
A2 Klaassen, Curtis D.
A2 Watkins III, John B.
SR Print(0)
ID 1113949325
T1 Toxicokinetics
T2 Casarett & Doullâ€™s Essentials of Toxicology, 3e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071847087
LK accesspharmacy.mhmedical.com/content.aspx?aid=1113949325
RD 2021/11/27
AB Toxicokinetics is the study of the modeling and mathematical description of the time course of disposition (absorption, distribution, biotransformation, and excretion) of xenobiotics in the whole organism.The apparent volume of distribution (Vd) is the space into which an amount of chemical is distributed in the body to result in a given plasma concentration.Clearance describes the rate of chemical elimination from the body in terms of volume of fluid containing chemical that is cleared per unit of time.The half-life of elimination (T1/2) is the time required for the blood or plasma chemical concentration to decrease by one-half.