RT Book, Section A1 Schnellmann, Rick G. A2 Klaassen, Curtis D. A2 Watkins III, John B. SR Print(0) ID 1113950318 T1 Toxic Responses of the Kidney T2 Casarett & Doull’s Essentials of Toxicology, 3e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071847087 LK accesspharmacy.mhmedical.com/content.aspx?aid=1113950318 RD 2024/03/28 AB The kidney contributes to total body homeostasis via its role in the excretion of metabolic wastes, the synthesis and release of renin and erythropoietin, and the regulation of extracellular fluid volume, electrolyte composition, and acid–base balance.Xenobiotics in the systemic circulation will be delivered to the kidney in relatively high amounts.The processes that concentrate urine also serve to concentrate potential toxicants in the tubular fluid.Renal transport, accumulation, and biotransformation of xenobiotics contribute to the susceptibility of the kidney to toxic injury.Numerous nephrotoxicants cause mitochondrial dysfunction via compromised respiration and ATP production, or some other cellular process, leading to either apoptosis or necrosis.