RT Book, Section
A1 Tokar, Erik J.
A1 Boyd, Windy A.
A1 Freedman, Jonathan H.
A1 Waalkes, and Michael P.
A2 Klaassen, Curtis D.
A2 Watkins III, John B.
SR Print(0)
ID 1113951613
T1 Toxic Effects of Metals
T2 Casarett & Doull’s Essentials of Toxicology, 3e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071847087
LK accesspharmacy.mhmedical.com/content.aspx?aid=1113951613
RD 2024/04/16
AB Persons  at  either  end  of  the  life  span,  young  children  or  elderly  people,  are  more  susceptible  to  toxicity  from  exposure  to  a  particular  level  of  metal  than  most  adults.Metals  that  provoke  immune  reactions  include  mercury,  gold,  platinum,  beryllium,  chromium,  and  nickel.Complexation  is  the  formation  of  a  metal  ion  complex  in  which  the  metal  ion  is  associated  with  a  charged  or  uncharged  electron  donor,  referred  to  as  a  ligand.Chelation  occurs  when  bidentate  ligands  form  ring  structures  that  include  the  metal  ion  and  the  two  ligand  atoms  attached  to  the  metal.Metal–protein  interactions  include  binding  to  numerous  enzymes,  the  metallothioneins,  nonspecific  binding  to  proteins  such  as  serum  albumin  or  hemoglobin,  and  specific  metal  carrier  proteins  involved  in  the  membrane  transport  of  metals.