RT Book, Section A1 Earle, Sandra B. A2 Nemire, Ruth E. A2 Kier, Karen L. A2 Assa-Eley, Michelle SR Print(0) ID 1117502162 T1 Designing Patient Treatment Plans: Pharmacokinetic Foundations T2 Pharmacy Student Survival Guide, 3e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071828475 LK accesspharmacy.mhmedical.com/content.aspx?aid=1117502162 RD 2024/03/29 AB Objectives: Upon completion of the chapter and exercises, the student pharmacist will be able toDefine components of a dosage regimen (dose rate and dose interval) and predict how they influence concentrations of drug in the plasma. (Css,avg and P:T).List the factors influencing the bioavailability of an orally administered drug.List the determinants of volume of distribution and why volume changes may or may not matter.List the determinants of renal clearance and determine how drugs and disease may alter renal clearance and thus alter Css,avg and/or P:T of a given drug cleared by the kidney.List the determinants of hepatic clearance and determine how drugs and disease may alter hepatic clearance and thus alter Css,avg and/or P:T of a given drug cleared by the liver.Given appropriate concentration-time data, calculate k, t½,Cmax, Cmin, and AUC for that drug in that patient.Explain the reasons for drug monitoring and how that will impact the patient's outcome.Discuss the attributes of extended-interval dosing and traditional dosing for aminoglycosides.